Description
NV-Clob Cream (Clobetasol Propionate) – Complete Reference
—
1. Pharmacokinetics
Absorption: Absorbed through intact skin; absorption increases with prolonged use, occlusion, damaged skin, or application over large surface areas.
Distribution: Limited systemic distribution when used as directed; higher systemic absorption possible with excessive use.
Metabolism: Metabolized primarily in the liver after systemic absorption.
Excretion: Excreted mainly via urine and bile.
Special Populations: Children are at higher risk of systemic absorption due to a larger skin surface area to body weight ratio.
—
2. Pharmacodynamics
Class: Super-potent topical corticosteroid.
Action: Anti-inflammatory, antipruritic, and vasoconstrictive.
Effect: Reduces inflammation, redness, swelling, and itching associated with corticosteroid-responsive dermatoses.
—
3. Mechanism of Action
Clobetasol suppresses the release of inflammatory mediators such as prostaglandins and leukotrienes.
It inhibits cytokine production and reduces capillary permeability, resulting in decreased inflammation and pruritus.
—
4. Specification
Form: Topical cream
Strength: Clobetasol Propionate 0.05% w/w
Appearance: White to off-white smooth cream
Route: For external use only
—
5. Clinical Indications
Psoriasis (except widespread plaque psoriasis)
Eczema and atopic dermatitis
Lichen planus
Discoid lupus erythematosus
Contact dermatitis
Other severe corticosteroid-responsive dermatoses
—
6. Dosage and Administration
Adults:
Apply a thin layer to the affected area once or twice daily.
Duration:
Use for short-term treatment (generally not exceeding 2 weeks).
Administration:
Rub gently into the skin until absorbed. Avoid occlusive dressings unless directed by a physician.
—
7. Precautions
Avoid use on face, groin, or axilla unless specifically prescribed.
Do not use on broken or infected skin without medical advice.
Prolonged use may cause skin atrophy and systemic effects.
Use cautiously in elderly patients and children.
—
8. Warnings
Adrenal Suppression: Risk with prolonged use, large doses, or occlusion.
Skin Reactions: Thinning of skin, striae, telangiectasia with extended use.
Pediatric Use: Increased risk of systemic toxicity in children.
Abrupt Discontinuation: Gradual tapering recommended after prolonged therapy.
—
9. Side Effects
Common:
Burning or stinging sensation
Itching
Dryness
Redness at application site
Serious (rare):
Skin atrophy
Hypopigmentation
Secondary infection
HPA axis suppression
Contact dermatitis
—
10. Drug Interactions
Minimal with topical use.
Increased systemic corticosteroid effects when used with other corticosteroids or under occlusive dressings.
—
11. Storage and Stability
Store below 30°C
Protect from heat and moisture
Keep out of reach of children
Shelf-life: 2–3 years
—
12. Additional Notes
Not for ophthalmic use.
Wash hands after application unless treating hands.
Patient Advice: Use only as prescribed; report worsening symptoms, skin thinning, or infection signs promptly
Reviews
There are no reviews yet.