Capsules CARFOLIC

Description

Capsules CARFOLIC

3×10

Carbonyl Iron 100 mg + Folic Acid 2 mg + Vitamin B12 15 mcg + Zinc Sulfate 1.5 mg + Vitamin C 75 mg

Pharmacokinetics

1. Carbonyl Iron:

Absorption: Slowly absorbed in the duodenum and upper jejunum, requiring gastric acid for optimal absorption.

Distribution: Binds to transferrin in plasma and is transported to bone marrow and liver.

Metabolism: Not metabolized; utilized in hemoglobin synthesis.

Excretion: Unabsorbed iron is excreted in feces.

 

2. Folic Acid:

Absorption: Rapidly absorbed in the small intestine.

Distribution: Circulates as 5-methyltetrahydrofolate and is stored in the liver.

Metabolism: Converted into active coenzyme forms.

Excretion: Excreted through urine.

 

3. Vitamin B12:

Absorption: Requires intrinsic factor for absorption in the ileum.

Distribution: Stored in the liver and transported via transcobalamin.

Metabolism: Converted to active forms (methylcobalamin and adenosylcobalamin).

Excretion: Eliminated via bile and urine.

 

4. Zinc Sulfate:

Absorption: Absorbed in the small intestine, but its bioavailability is affected by phytates.

Distribution: Found in muscles, bones, and liver.

Metabolism: Not metabolized; functions as an enzymatic cofactor.

Excretion: Mainly excreted in feces, with some loss in urine and sweat.

 

5. Vitamin C:

Absorption: Efficiently absorbed in the small intestine via active transport.

Distribution: Concentrated in leukocytes, adrenal glands, and eyes.

Metabolism: Converted to dehydroascorbic acid in the liver.

Excretion: Excreted in urine.

 

Pharmacodynamics

Carbonyl Iron: Essential for hemoglobin formation, oxygen transport, and prevention of iron-deficiency anemia.

Folic Acid: Crucial for DNA synthesis, red blood cell formation, and neural tube development during pregnancy.

Vitamin B12: Supports neurological function, red blood cell production, and DNA synthesis.

Zinc Sulfate: Plays a key role in immune function, wound healing, and enzymatic reactions.

Vitamin C: Enhances iron absorption, acts as an antioxidant, and supports immune function.

Precautions & Warnings

Iron Overload: Avoid in patients with hemochromatosis or hemosiderosis.

Gastrointestinal Issues: High doses of iron may cause constipation, nausea, or stomach upset.

Renal Impairment: Use with caution in patients with kidney disease, especially for zinc and vitamin C.

Drug Interactions:

Iron can interfere with the absorption of tetracyclines and fluoroquinolones.

Vitamin C may enhance iron absorption but can also increase the risk of kidney stones.

 

Dosage & Administration

Recommended Dosage:

Adults: Usually 1 tablet daily or as directed by a physician.

Pregnant Women: May require higher doses based on doctor’s advice.

Children: Use only under medical supervision.

Administration: Best taken on an empty stomach for better absorption, but if gastric irritation occurs, it can be taken with food.

Overall Benefits of This Combination

Effective in treating iron-deficiency anemia.

Supports red blood cell production and oxygen transport.

Enhances immune function and metabolism.

Improves neurological health and cognitive function.

Helps in pregnancy by preventing neural tube defects.

Possible Side Effects

Common: Nausea, constipation, stomach discomfort, and dark stools (due to iron).

Rare: Allergic reactions, diarrhea, or metallic taste in the mouth.

Long-Term Use Risks: Excessive iron intake can lead to toxicity, and high zinc levels may interfere with copper absorption.

Conclusion

This combination of iron, folic acid, vitamin B12, zinc, and vitamin C is highly effective for managing anemia, boosting immunity, and supporting overall health. However, it should be taken under medical supervision to avoid side effects and interactions.