Esmodone DSR Capsules

Description

Esmodone DSR Capsules (Esomeprazole 40mg & Domperidone 30mg)
1. Pharmacokinetics
Esomeprazole:
Absorption: Rapid absorption, peak plasma concentration within 1–2 hours.
Metabolism: Metabolized in the liver by the P450 system.
Half-life: Approximately 1–1.5 hours.
Domperidone:
Absorption: Well absorbed, with reduced bioavailability due to first-pass metabolism.
Half-life: Approximately 7–9 hours.
2. Pharmacodynamics
Esomeprazole: Proton pump inhibitor, reduces stomach acid production.
Domperidone: Dopamine antagonist, enhances gastric motility.
3. Clinical Indications
GERD: Treatment of heartburn and esophagitis.
Peptic Ulcers: Healing and prevention.
Delayed Gastric Emptying: Reduces symptoms of nausea, vomiting, and bloating.
Nausea & Vomiting: Effective in controlling nausea and vomiting.
4. Dosage and Administration
Dosage: 1 capsule (40mg Esomeprazole & 30mg Domperidone) once daily before meals.
Administration: Take 30 minutes before meals, swallowing the capsule whole.
5. Precautions
Allergy: Contraindicated in patients with hypersensitivity to Esomeprazole, Domperidone, or any components of the formulation.
Cardiac Risk: Use cautiously in patients with heart conditions due to potential QT interval prolongation.
Pregnancy: Use only when necessary in pregnancy.
6. Food and Drug Interactions
Esomeprazole may reduce the absorption of certain drugs due to its effect on stomach acid levels.
7. Monitoring Recommendations
Long-term use should be monitored for magnesium levels and ECG in patients with a history of cardiac disease.
8. Side Effects
Esomeprazole: Headache, nausea, abdominal pain, and flatulence.
Domperidone: Dry mouth, abdominal cramps, and potential cardiac side effects in prolonged use.
9. Storage and Stability
Storage: Store below 30°C, in a dry place, away from direct sunlight.
Shelf life: 2–3 years.
Note: Keep out of reach of children