NV-Cort 6mg Tablets (Deflazacort)

Description

NV-Cort 6mg Tablets (Deflazacort) – Complete Reference

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1. Pharmacokinetics

Absorption: Rapidly absorbed after oral administration.

Bioavailability: High oral bioavailability.

Distribution: Widely distributed in body tissues; moderate plasma protein binding.

Metabolism: Prodrug converted in the liver to its active metabolite (21-desacetyl deflazacort).

Excretion: Mainly excreted via urine.

Half-life: Approximately 1.5–2 hours.

Special Populations: Dose adjustment may be required in hepatic or renal impairment.

 

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2. Pharmacodynamics

Class: Synthetic glucocorticoid.

Action: Anti-inflammatory, immunosuppressive, and anti-allergic.

Potency: Comparable efficacy to prednisolone with relatively less impact on bone metabolism.

 

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3. Mechanism of Action

Suppresses inflammatory gene expression by inhibiting cytokines, prostaglandins, and leukotrienes.

Reduces capillary permeability and immune cell migration.

Modulates immune response to decrease inflammation and hypersensitivity reactions.

 

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4. Specification

Form: Film-coated tablet

Strength: Deflazacort 6mg

Appearance: White to off-white tablet

Route: Oral administration

 

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5. Clinical Indications

Allergic disorders

Bronchial asthma

Rheumatoid arthritis

Autoimmune diseases

Skin diseases (eczema, dermatitis)

Inflammatory bowel disease

Nephrotic syndrome

Muscular dystrophy

Other inflammatory or immunosuppressive conditions

 

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6. Dosage and Administration

Adults:
Dose depends on condition and severity (commonly 6–30mg daily).

Pediatrics:
Dose based on body weight and clinical response.

Administration:
Take orally with or after food.

Long-term Therapy:
Use lowest effective dose; taper gradually to avoid adrenal insufficiency.

 

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7. Precautions

Use cautiously in diabetes, hypertension, osteoporosis, glaucoma, and peptic ulcer disease.

Increased risk of infections during therapy.

Monitor blood pressure, blood glucose, and bone density with prolonged use.

Vaccination with live vaccines should be avoided.

 

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8. Warnings

Adrenal Suppression: Risk with long-term use or sudden withdrawal.

Infection Risk: May mask signs of infection.

Psychiatric Effects: Mood changes, insomnia, or behavioral disturbances possible.

Growth Suppression: Possible in children with prolonged therapy.

 

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9. Side Effects

Common:

Increased appetite

Weight gain

Indigestion

Mood changes

Fluid retention

Serious (rare):

Osteoporosis

Cushingoid features

Hyperglycemia

Hypertension

Peptic ulcer

Cataracts or glaucoma

 

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10. Drug Interactions

NSAIDs: Increased risk of gastrointestinal bleeding.

Antidiabetics: Reduced glucose-lowering effect.

Diuretics: Increased risk of hypokalemia.

Anticonvulsants: Reduced steroid efficacy.

Vaccines: Reduced immune response.

 

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11. Storage and Stability

Store below 25°C

Protect from moisture and light

Keep out of reach of children

Shelf-life: 2–3 years

 

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12. Additional Notes

Prefer morning dosing to mimic natural cortisol rhythm.

Gradual dose reduction required after prolonged use.

Patient Advice: Do not stop medication abruptly; report signs of infection, black stools, or vision changes immediately