NV-LINE 10/0.5 MG TABLETS

Description

NV-LINE 10/0.5 MG TABLETS

Nortriptyline 10mg + Fluphenazine 0.5mg (Film-Coated Tablet) – Detailed Explanation

This combination medication contains Nortriptyline, a tricyclic antidepressant (TCA), and Fluphenazine, a typical antipsychotic. It is mainly used to treat depression, anxiety, and certain psychiatric disorders by regulating brain chemicals that influence mood, emotions, and thought processes.

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Pharmacokinetics (How the Drug Moves in the Body)

1. Absorption:

The drug is well-absorbed in the gastrointestinal tract after oral intake.

The film coating helps improve absorption and protects the drug from stomach acid.

 

2. Metabolism:

Nortriptyline is metabolized in the liver by the CYP2D6 enzyme, converting it into active metabolites.

Fluphenazine is also processed in the liver and has a slow breakdown rate, leading to prolonged effects.

 

3. Half-Life & Duration:

Nortriptyline: 18–90 hours, providing long-lasting antidepressant effects.

Fluphenazine: 14–16 hours for the oral form, but its action in the brain lasts longer.

 

4. Excretion:

Mostly eliminated through urine and bile after metabolism.

 

 

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Pharmacodynamics (How the Drug Works in the Body)

1. Nortriptyline (Tricyclic Antidepressant – TCA)

Increases serotonin & norepinephrine levels by blocking their reuptake.

Improves mood, concentration, sleep, and energy levels.

Can also help with chronic pain and migraines due to its effect on nerve pathways.

2. Fluphenazine (Typical Antipsychotic – Phenothiazine Group)

Blocks dopamine D2 receptors in the brain, helping control hallucinations, delusions, and agitation.

Helps reduce anxiety and emotional instability.

Has a mild sedative effect, making it useful for restlessness and agitation.

 

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Key Uses of Nortriptyline + Fluphenazine

✅ Major Depressive Disorder (MDD) with Anxiety
✅ Schizophrenia & other psychotic disorders
✅ Bipolar Disorder (Depressive Phase, with agitation or psychosis)
✅ Chronic pain & migraine management (off-label use)
✅ Agitation in elderly patients (with caution, under medical supervision)

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Special Features of This Combination

✔ Dual Action: Combines antidepressant and antipsychotic benefits.
✔ Prolonged Effect: Once or twice daily dosing provides long-lasting symptom control.
✔ Film-Coated Tablet: Improves swallowing and absorption while protecting against stomach irritation.

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Side Effects

⚠ Common Side Effects (Mild & Manageable):

Dry mouth, dizziness, drowsiness

Constipation, weight changes

Blurred vision

⚠ Serious Side Effects (Rare but Require Attention):

Tardive Dyskinesia (involuntary muscle movements) – from Fluphenazine

QT Prolongation (heart rhythm issues) – from Nortriptyline

Hypotension (low blood pressure), dizziness upon standing

Neuroleptic Malignant Syndrome (very rare but serious reaction with fever, confusion, muscle rigidity)

 

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Benefits of This Combination

⭐ Treats both depression and psychosis in one medication
⭐ Effective for anxiety, agitation, and mood swings
⭐ Long-acting, reducing the need for multiple daily doses

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Why is This Combination Made?

For patients experiencing both depression and psychotic symptoms.

To improve treatment response for severe mood disorders.

To reduce the number of medications a patient needs to take.

💊 Always use under medical supervision for best results and safety.