Pantodone DSR Capsule

Description

Pantodone DSR Capsule

1. Pharmacokinetics

Pantoprazole 40mg ER

Absorption: Rapidly absorbed orally; bioavailability ~77%.

Distribution: Widely distributed; ~98% plasma protein binding.

Metabolism: Hepatic metabolism via CYP2C19.

Excretion: Primarily in urine (~71%) and feces (~18%).

Half-life: 1–2 hours; prolonged action due to enteric coating.

Domperidone 30mg SR

Absorption: Well absorbed; peak plasma concentration in 3–4 hours (sustained release).

Distribution: ~91–93% plasma protein binding.

Metabolism: Hepatic metabolism via CYP3A4.

Excretion: Mainly via urine and bile.

Half-life: 7–9 hours (sustained release formulation).

 

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2. Pharmacodynamics

Class: Proton pump inhibitor (Pantoprazole) + Dopamine antagonist (Domperidone)

Action:

Pantoprazole: Inhibits gastric acid secretion by blocking H+/K+ ATPase in parietal cells.

Domperidone: Increases gastrointestinal motility and accelerates gastric emptying; antiemetic effect.

Effect: Reduces acid-related symptoms and relieves nausea, vomiting, and bloating.

 

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3. Mechanism of Action

Pantoprazole: Binds to gastric parietal cells’ proton pumps, suppressing basal and stimulated gastric acid secretion.

Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and GI tract, enhancing motility and reducing nausea/vomiting.

 

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4. Specification

Form: Capsule, Extended/Sustained Release

Strength: Pantoprazole 40mg ER + Domperidone 30mg SR

Appearance: Two-in-one capsule, usually bicolored

Route: Oral

 

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5. Clinical Indications

Gastroesophageal reflux disease (GERD)

Peptic ulcer disease (duodenal or gastric ulcer)

Gastritis and dyspepsia

Nausea and vomiting associated with delayed gastric emptying

Zollinger-Ellison syndrome (acid hypersecretion)

 

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6. Dosage and Administration

Adults: 1 capsule once daily, 30 minutes before meals, or as prescribed by a physician

Administration: Swallow whole; do not crush or chew.

Duration: As advised by healthcare professional; usually 2–8 weeks for GERD or ulcers

 

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7. Precautions

Hepatic or renal impairment: Use with caution

History of cardiac arrhythmias: Monitor for QT prolongation

Not recommended for children under 12 years without medical advice

 

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8. Warnings

May mask symptoms of gastric malignancy; rule out cancer if persistent symptoms

Rare risk of severe arrhythmias with domperidone in high doses or cardiac disease

Long-term PPI therapy may increase risk of vitamin B12 deficiency, hypomagnesemia, or bone fractures

 

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9. Side Effects

Common:

Headache, dizziness

Abdominal pain, diarrhea, constipation

Nausea or bloating

Serious (rare):

Liver enzyme elevation (Pantoprazole)

QT prolongation, palpitations (Domperidone)

Allergic reactions (rash, swelling, anaphylaxis)

 

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10. Drug Interactions

Pantoprazole may reduce absorption of drugs requiring acidic pH (ketoconazole, atazanavir)

Domperidone may interact with QT-prolonging drugs, CYP3A4 inhibitors, or antifungals

Avoid concurrent use with other prokinetic or antiemetic drugs unless prescribed

 

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11. Storage and Stability

Store below 25°C

Protect from light and moisture

Keep out of reach of children

Shelf-life: 2–3 years

 

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12. Additional Notes

Take 30 minutes before meals for optimal acid suppression

Do not exceed recommended dose; seek medical advice for persistent or worsening symptoms

Patient Advice: Report severe abdominal pain, persistent vomiting, jaundice, or irregular heartbeat immediately