Description
Raydon DSR Capsule
—
1. Pharmacokinetics
Rabeprazole 20mg ER
Absorption: Rapidly absorbed; peak plasma concentration in 2–5 hours.
Distribution: Widely distributed; ~96% plasma protein binding.
Metabolism: Extensive hepatic metabolism via CYP2C19 and CYP3A4.
Excretion: Mainly in urine (~90%) as metabolites; minor in feces.
Half-life: ~1–2 hours; prolonged effect due to enteric coating.
Domperidone 30mg SR
Absorption: Well absorbed; peak plasma concentration in 3–4 hours (sustained release).
Distribution: Plasma protein binding ~91–93%.
Metabolism: Hepatic metabolism via CYP3A4.
Excretion: Urine and bile; unchanged and as metabolites.
Half-life: 7–9 hours (sustained release formulation).
—
2. Pharmacodynamics
Class: Proton pump inhibitor (Rabeprazole) + Dopamine antagonist/prokinetic (Domperidone)
Action:
Rabeprazole: Suppresses gastric acid secretion by inhibiting H+/K+ ATPase in parietal cells.
Domperidone: Enhances gastrointestinal motility and prevents nausea and vomiting.
Effect: Reduces acid-related symptoms, bloating, and gastric discomfort; improves gastric emptying.
—
3. Mechanism of Action
Rabeprazole: Irreversibly binds to gastric proton pumps, suppressing both basal and stimulated gastric acid secretion.
Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and GI tract, promoting gastric motility and preventing nausea/vomiting.
—
4. Specification
Form: Capsule, Extended/Sustained Release
Strength: Rabeprazole 20mg ER + Domperidone 30mg SR
Route: Oral
—
5. Clinical Indications
Gastroesophageal reflux disease (GERD)
Functional dyspepsia
Gastritis and peptic ulcer disease
Nausea, vomiting, and bloating associated with delayed gastric emptying
Acid-related gastrointestinal disorders with motility dysfunction
—
6. Dosage and Administration
Adults: 1 capsule once daily, 30 minutes before meals, or as prescribed
Administration: Swallow whole; do not crush or chew
Duration: As advised by healthcare professional
—
7. Precautions
Hepatic or renal impairment: Use with caution
Not recommended for children under 18 years without medical supervision
Avoid in patients with hypersensitivity to Rabeprazole or Domperidone
—
8. Warnings
May mask symptoms of gastric malignancy; rule out serious GI conditions if persistent
Rare risk of cardiac arrhythmias with Domperidone (QT prolongation)
Long-term PPI therapy may lead to vitamin B12 deficiency, hypomagnesemia, or bone fractures
—
9. Side Effects
Common:
Headache, dizziness
Abdominal pain, diarrhea, constipation
Nausea, bloating
Serious (rare):
QT prolongation, palpitations
Liver enzyme elevation
Allergic reactions (rash, swelling, anaphylaxis)
—
10. Drug Interactions
Rabeprazole may reduce absorption of drugs requiring acidic pH (e.g., ketoconazole, atazanavir)
Domperidone interacts with QT-prolonging drugs, CYP3A4 inhibitors, and antifungals
Avoid concurrent use with other prokinetic or antiemetic drugs unless prescribed
—
11. Storage and Stability
Store below 25°C
Protect from light and moisture
Keep out of reach of children
Shelf-life: 2–3 years
—
12. Additional Notes
Take 30 minutes before meals for optimal effect
Complete the full course as prescribed
Patient Advice: Report severe abdominal pain, persistent vomiting, palpitations, or jaundice immediately
Reviews
There are no reviews yet.